I am fascinated by the fact that DNA
works. I am fascinated by the idea that
chemistry and physics are intimately involved in how it works. I want to know more about why and how the
apparently most important chemical in our bodies works.
When I was at school, my best subject
was Chemistry. Yet I specialised in
physics.
Physics teaches that there is an
immutable set of laws that govern the behaviour of all matter. These laws govern the miniscule, the
infinitesimal and the macro scale of our universe. One of those laws, talks about all things
being local. Nothing exists on the grand
scale, except through the local interactions of matter, the electrical and
atomic forces that exist on different atoms and molecules, the spins of
molecules, and the multidimensional folding of chains of atoms. The local interactions extend upwards through
the emergent systems of larger scales.
But those emergent systems only exist because of the underlying chemical
and physical properties of matter.
A chemical law that emerges from the
underlying physics is that all inter-matter dependencies rely on the exchange
of energy. Chemical reactions can be
exothermic or they can be endothermic.
Often, reactions exist in some kind of equilibrium, where a continuous
exchange of energy (thermal and chemical?) results in a stasis, an apparently
static arrangement. Maybe there is
energy in the environment that varies and changes the nature of the
stasis. As the environmental energy
levels change so does the equilibrium point of a chemical reactions.
Lastly there is the fundamental law
of physics, that of Entropy. Everything
is going to slow down, and lead to the ultimate energy death of the universe.
How does DNA operate in such a way
not to violate these laws? What are the
basic mechanisms of cell biology that enable the cell to function? When scientists talk about DNA generating
enzymes that influence behaviour on an organism level, what is the basic
energy equation that enables this to occur and then to continue to occur? When a mitochondrion delivers a molecule of
ATP how can it do that? What “benefit”
does the mitochondrion receive in return?
What is the energy gradient through a cell, that enables transport
through a cell and then beyond its membrane?
How does DNA function over
distance? What is the driving force that
leads to its replication? Why and how?
Everything else flows from that. Evolution, human society. It all depends on the mechanisms, physical
and chemical, of DNA.
Whether a study of biochemistry will reveal
answers to these questions remains to be seen.
Maybe the study will show that I am asking the wrong questions. Whatever the answers, I am taking an
undergraduate course in biochemistry.
There may be other ways of doing this, but the idea of getting a degree
in the subject is appealing, now in my retirement.
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